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ImmVira to Test its 3-in-1 Virus Delivery Product with Roche’s MEK Inhibitor

publication date: Apr 20, 2022

Shenzhen ImmVira plans to establish a partnership with Roche to conduct US clinical trials that combine ImmVira's 3-in-1 herpes simplex virus product with Roche's MEK inhibitor, cobimetinib. ImmVira’s MVR-T3011 is delivered by an oncolytic herpes simplex virus (oHSV) that is a genetically engineered oHSV with replication potency in tumor cells. It incorporates two exogenous genes, a PD-1 antibody and IL-12, to enhance immune responses in the tumor microenvironment. ImmVira believes MEK inhibitors augment oHSV oncolytic activity in BRAF V600E mutated cells and offer synergistic advantages. More details....

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