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Inmagene Approved to Start Phase I Trial of Novel BTK Inhibitor

publication date: May 20, 2022

Inmagene, a Shanghai- Diego biopharma, was approved to start a Phase I US trial of its third-gen BTK inhibitor. The company describes IMG-004 as a highly selective and brain permeable non-covalent, reversible small molecule inhibitor for inflammatory/autoimmune diseases that require long-term treatment. IMG-004 is one of four novel pre-clinical immunological candidates that Inmagene in-licensed from HutchMed last year in a deal worth up to $920 million. BTK, a non-receptor intracytoplasmic tyrosine kinase, is involved in the innate and adaptive immune responses of specific immune-mediated diseases. More details....

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