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TransThera to Start US Trials of Novel BTK Inhibitor

publication date: Feb 18, 2022

Nanjing TransThera Sciences was granted permission to start US trials of its non-covalent reversible Bruton's Tyrosine Kinase (BTK) inhibitor in patients with B-cell lymphomas. The company said its non-covalent BTK candidate, TT-01488, is differentiated from the five already-approved BTK drugs because each of the five form covalent bonds with the C481 site of BTK. When the C481S mutation occurs, patients become resistant to these drugs. The global market for BTK drugs is over $7 billion and growing, especially in China. More details....

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