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Zhongze Completes China Dose Escalation Trial for Schizophrenia Therapy

publication date: Apr 1, 2022

Shanghai Zhongze Therapeutics successfully completed a China Phase I dose escalating study in healthy volunteers of its self-developed therapy for schizophrenia. ZZ6398 is the first pan-antagonist of D2, D3, 5-HT1A and 5-HT2A receptors designed to treat cognitive impairment associated with schizophrenia by fine-tuning the D2/D3 selectivity and 5-HT1A antagonism. Zhongze reported the candidate was well tolerated with a better-than-expected PK profile. The company develops neurological and psychiatric products for unmet needs, with one in-licensed product and two clinical stage CNS candidates and three molecules in pre-clinical development. More details....

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